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The receptor tyrosine kinase (RTK) pathway is carefully regulated by a variety of positive and negative feedback loops. [24] Because RTKs coordinate a wide variety of cellular functions such as cell proliferation and differentiation, they must be regulated to prevent severe abnormalities in cellular functioning such as cancer and fibrosis.
Many receptor enzymes have closely related structure and receptor tyrosine kinase activity, and it has been determined that the foundational or prototypical receptor enzyme is insulin. [2] Insulin receptor substrates IRS2 and IRS3 each have unique characteristic tissue function and distribution that serves to enhance signaling capabilities in ...
The abbreviation trk (often pronounced 'track') stands for tropomyosin receptor kinase or tyrosine receptor kinase [1] [4] (and not "tyrosine kinase receptor" nor "tropomyosin-related kinase", as has been commonly mistaken). The family of Trk receptors is named for the oncogene trk, whose identification led to the discovery of its first member ...
Receptor-linked tyrosine kinases, such as the epidermal growth factor receptor (EGFR), are activated by extracellular ligands, such as the epidermal growth factor (EGF). Binding of EGF to the EGFR activates the tyrosine kinase activity of the cytoplasmic domain of the receptor. The EGFR becomes phosphorylated on tyrosine residues.
MuSK (for Muscle-Specific Kinase) [1] is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. [2] It is activated by a nerve-derived proteoglycan called agrin , [ 3 ] which is similarly also required for neuromuscular junction formation.
21846 Ensembl ENSG00000066056 ENSMUSG00000033191 UniProt P35590 Q06806 RefSeq (mRNA) NM_001253357 NM_005424 NM_011587 RefSeq (protein) NP_001240286 NP_005415 NP_035717 Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.33 – 118.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE ...
This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein. [6]
Dimerization of RTKs leads to autophosphorylation of tyrosine in the catalytic core of the dimer, and finally stimulation of the tyrosine kinase activity and cell signaling. [21] It is thus an example of a trans-autophosphorylation reaction, where one receptor subunit of the dimer phosphorylates the other subunit. [22]
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