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  2. Genetic causes of type 2 diabetes - Wikipedia

    en.wikipedia.org/wiki/Genetic_causes_of_type_2...

    However, single nucleotide polymorphism (SNP) is one of many mechanisms that leads to increased risk for type 2 diabetes. To locate genes and loci that are responsible for the risk of type 2 diabetes, genome wide association studies (GWAS) was utilized to compare the genomes of diabetic patient group and the non-diabetic control group. [4]

  3. Thrifty gene hypothesis - Wikipedia

    en.wikipedia.org/wiki/Thrifty_gene_hypothesis

    Prentice et al. [17] predicted that the emerging molecular genetics field would ultimately provide a way to test between the adaptive 'thrifty gene' idea and the non-adaptive 'drifty gene' idea because it would be possible to find signatures of positive selection in the human genome, at genes that are linked to both obesity and type 2 diabetes ...

  4. Maturity-onset diabetes of the young - Wikipedia

    en.wikipedia.org/wiki/Maturity-onset_diabetes_of...

    Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes , MODY is a form of the conditions known as monogenic diabetes.

  5. Glucokinase - Wikipedia

    en.wikipedia.org/wiki/Glucokinase

    Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Glucokinase (GK) is a hexokinase isozyme , related homologously to at least three other hexokinases. [ 4 ] All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and ...

  6. MODY 2 - Wikipedia

    en.wikipedia.org/wiki/MODY_2

    MODY 2 or GCK-MODY is a form of maturity-onset diabetes of the young. [1] It is due to any of several mutations in the GCK gene on human chromosome 7 for glucokinase. [2] Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion as the glucose exceeds about 90 mg/dl (5 mM).

  7. Type 2 diabetes - Wikipedia

    en.wikipedia.org/wiki/Type_2_diabetes

    Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to type 1 diabetes and gestational diabetes. [1] In type 1 diabetes, there is a lower total level of insulin to control blood glucose, due to an autoimmune -induced loss of insulin-producing beta cells in the pancreas .

  8. Epidemiology of diabetes - Wikipedia

    en.wikipedia.org/wiki/Epidemiology_of_diabetes

    Diabetes currently affects more than 74 million Indians, which is more than 8.3% of the adult population. [1] It is estimated to be around 57% of the current cases of diabetes to be undiagnosed. [17] Among young and middle aged adults the prevalence of diabetes is 6.7% and prediabetes is 5.6% according to the National Family Health Survey-4. [18]

  9. Wolfram syndrome - Wikipedia

    en.wikipedia.org/wiki/Wolfram_syndrome

    Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders including neurodegeneration.

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