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Fexofenadine, sold under the brand name Allegra among others, [10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. [ 11 ] Therapeutically, fexofenadine is a selective peripheral H 1 blocker .
H 1 antagonists, also called H 1 ... 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine: 25 mg 2–3 hours 10–12 hours ... Fexofenadine (Allegra) [21] [22]
H 1-antihistamines work by binding to histamine H 1 receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary nucleus in the brain. Antihistamines that target the histamine H 1-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and
There are several splice variants of H 3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H 1 and H 2 are quite different from H 3 and H 4 in their activities. H 1 causes an increase in PIP 2 hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.
It contains fexofenadine, as the hydrochloride, an antihistamine; and pseudoephedrine, as the hydrochloride, a nasal decongestant. [ 2 ] In 2021, it was the 279th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.. H 1 agonists promote wakefulness. [1]H 2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine.