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The first clinical manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. [7] Paget's disease of right pelvic bone. Man of 80 years age. Paget's disease may be diagnosed using one or more of the following tests: Pagetic bone has a characteristic appearance on X-rays. A skeletal survey is therefore indicated.
Elevated levels are also associated with diabetes, hypertension, and cardiovascular disease; it was found that elevated levels are associated with elevated serum C-reactive protein (CRP), which could reflect an inflammatory and atherogenic milieu, possibly an alternative cause for elevated serum alkaline phosphatase. [10] Chronic kidney disease ...
Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.
Also, the level of alkaline phosphatase increases if there is active bone formation occurring, as the enzyme is a byproduct of osteoblast activity (such as the case in Paget's disease of bone). [57] The level of alkaline phosphatase is much more elevated in metastatic prostate cancer cells than non-metastatic prostate cancer cells. [61] High ...
Biochemical studies reveal hypophosphatemia (low blood phosphate), elevated alkaline phosphatase and low serum 1,25 dihydroxyvitamin D levels. Routine laboratory tests may not include serum phosphate levels and this can result in considerable delay in diagnosis. Even when low phosphate is measured, its significance is often overlooked.
Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. Most commonly these disorders are caused by deficiencies of minerals such as calcium, phosphorus, magnesium or vitamin D leading to dramatic clinical disorders that are commonly reversible once the underlying defect has been treated.
Alkaline phosphatase Parathyroid hormone Comments Osteopenia: unaffected unaffected normal unaffected decreased bone mass Osteopetrosis: unaffected unaffected elevated unaffected [citation needed] thick dense bones also known as marble bone Osteomalacia and rickets: decreased decreased elevated elevated soft bones Osteitis fibrosa cystica: elevated
My Alkaline phosphatase is extremely high. Who could tell me why that is, and how our body recieves Alkaline phosphatase (i.e. what kind of food contains Alkaline phosphatase). How could I make it lower..Please help ALP is a generally considered a marker of high bone activity - it is secreted by osteoblasts (bone forming cells). High ALP is ...