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The first Iteration was prior to 1998. In 1999, the FDA released version 2.0. CTCAE version 4.0 in 2009 with an update to y version 4.03 in 2010. [2] The current version 5.0 was released on November 27, 2017. Many clinical trials, now extending beyond oncology, encode their observations based on the CTCAE system. It uses a range of grades from ...
However the specification documents were unclear which led to criteria adjustments and inconsistent conclusions. In the mid-1990s, an International Working Party was created to simplify and standardize response criteria; it then published RECIST in 2000. These new criteria have been widely adopted and embraced by the regulatory authorities. [1]
[3] [4] It was an MS-DOS batch file on 5.25" floppy disks and released in 1985. [5] MS-DOS continued to be the only supported operating system until the release of Epi Info 2000, which was written in Microsoft's Visual Basic and became the first Windows-compatible version.
Steve Guttenberg hit the ground running to help people impacted by the fires in Pacific Palisades — and he was almost unrecognizable. The flames first began around 10:30 a.m. local time on ...
Cocoa was the top-performing commodity of 2024. The price of the bean surged as headwinds battered key producers. Prices are likely to stay high into 2025, analysts at ING said.
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iText is a library for creating and manipulating PDF files in Java and . NET.It was created in 2000 and written by Bruno Lowagie. The source code was initially distributed as open source under the Mozilla Public License or the GNU Library General Public License open source licenses.
December 18, 2024 at 4:57 AM. Danielle Bradley and Ashling Graham say they have been let down by the justice system after their father's killer went on the run from prison once again [BBC]