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www.hsd2.org: Harrison School District 2 is the southern school district of Colorado Springs, Colorado, United States. As of 2013 it had about 11,000 students. [2]
www.hsd2.org /hhs Harrison High School ( HHS ) is a public high school near the junction of Interstate 25 and Circle Drive on the southwest side of Colorado Springs, Colorado . It is one of two high schools in the Harrison School District 2 .
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15484 Ensembl ENSG00000176387 ENSMUSG00000031891 UniProt P80365 P51661 RefSeq (mRNA) NM_000196 NM_008289 RefSeq (protein) NP_000187 NP_032315 Location (UCSC) Chr 16: 67.43 – 67.44 Mb Chr 8: 106.25 – 106.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is ...
The efferent projections (axonal output) of HSD2 neurons have been investigated to a significant degree using conventional neuroanatomical tracers.Their primary output targets are the pre-locus coeruleus (pre-LC), the innermost portion of the external lateral parabrachial subnucleus (PBel), and the anterior, ventrolateral bed nucleus of the stria terminalis (BSTvl). [8]
Cushing's Disease, synonymous with hypercortisolism, involves overwhelming the cortisol-neutralizing ability of 11β-HSD2 with high concentrations of cortisol. [10] This allows cortisol to outcompete aldosterone and bind to mineralocorticoid receptors, resulting in the activation of several pathways that increase blood pressure.
Apparent mineralocorticoid excess is an autosomal recessive [2] disorder causing hypertension (high blood pressure), hypernatremia (increased blood sodium concentration) and hypokalemia (decreased blood potassium concentration).
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