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NLPHL is an uncommon sub-type of Hodgkin lymphoma, making up 5-10% of Hodgkin lymphomas. [3] It is distinguished from classic Hodgkin lymphoma by the presence of CD20 positive lymphocyte predominant cells, also known as popcorn cells due to their polylobated nuclei, which look like popcorn. [3] [4] [5]
Mummified RSCs (compact nucleus, basophilic cytoplasm, no nucleolus) are also associated with classical Hodgkin's lymphoma while popcorn cells (small cell with hyper-lobulated nucleus and small nucleoli) are lymph histiocytic (L-H) variant of Reed–Sternberg cells and are associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL).
The two major types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. [5] About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus (EBV) and these are generally the classic form. [3] [11] Other risk factors include a family history of the condition and having HIV/AIDS.
Nodular sclerosing Hodgkin lymphoma ("NSHL") or Nodular sclerosis is a form of Hodgkin's lymphoma [1] that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years.
Ann Arbor staging is the staging system for lymphomas, both in Hodgkin's lymphoma (formerly designated Hodgkin's disease) and non-Hodgkin lymphoma (abbreviated NHL). It was initially developed for Hodgkin's, but has some use in NHL. It has roughly the same function as TNM staging in solid tumors.
CCL17 is mainly responsible for the presence of large amounts of T-helper and T-regulatory cells in the tumor microenvironment, which is considered a hallmark of Hodgkin lymphoma. [15] Levels of CCL17 in serum are ~400 times higher in Hodgkin lymphoma patients than in healthy controls and are strongly associated with tumor volume, disease stage ...
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