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In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. [1] In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
23186 217864 Ensembl ENSG00000089902 ENSMUSG00000037896 UniProt Q9UKL0 Q8CFE3 RefSeq (mRNA) NM_015156 NM_198023 RefSeq (protein) NP_055971 NP_932140 Location (UCSC) Chr 14: 102.59 – 102.73 Mb Chr 12: 111.01 – 111.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene. Function This gene ...
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid). [7] In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor).
254251 209707 Ensembl ENSG00000178177 ENSMUSG00000015882 UniProt Q8N3X6 Q3U285 RefSeq (mRNA) NM_001166139 NM_153686 NM_001163073 NM_172153 NM_178142 NM_001359871 NM_001359872 NM_001359873 NM_001359874 RefSeq (protein) NP_001159611 NP_710153 NP_001352587 NP_001352588 NP_001352589 NP_001352590 NP_001352591 NP_001352592 NP_001352594 NP_001156545 NP_742165 NP_835278 NP_001346800 NP_001346801 NP ...
20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The nuclear receptor co-repressor 1 also known as thyroid ...
66556 Ensembl ENSG00000175550 ENSMUSG00000024914 UniProt Q14919 Q9D6N5 RefSeq (mRNA) NM_006442 NM_001291080 NM_024176 RefSeq (protein) NP_006433 NP_001278009 NP_077138 Location (UCSC) Chr 11: 65.92 – 65.92 Mb Chr 19: 5.47 – 5.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene. Transcriptional ...
54880 71458 Ensembl ENSG00000183337 ENSMUSG00000040363 UniProt Q6W2J9 Q8CGN4 RefSeq (mRNA) NM_001123383 NM_001123384 NM_001123385 NM_001130139 NM_017745 NM_020926 NM_001168321 NM_029510 NM_175044 NM_175045 NM_175046 RefSeq (protein) NP_001116855 NP_001116856 NP_001116857 NP_060215 NP_001161793 NP_083786 NP_778209 NP_778210 NP_778211 Location (UCSC) Chr X: 40.05 – 40.18 Mb Chr X: 11.9 – 12. ...