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Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re-+ perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction , ischemic stroke , acute kidney injury , trauma ...
Vasoplegic syndrome is defined as low systemic vascular resistance (SVR index <1,600 dyn∙sec/cm 5 /m 2) and high cardiac output (cardiac index >2.5 L/min/m 2) within the first 4 postoperative hours. [3]
Kidney ischemia [1] is a disease with a high morbidity and mortality rate. [2] Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. More complications happen when failure of the kidney functions result in toxicity in various parts of the body which may cause septic shock, hypovolemia, and a need for surgery. [3]
Vascular surgery, internal medicine, ... The majority of persons affected make a full recovery. The mortality rate is 4.3%. [9] ... With reperfusion comes ischemia ...
The signs and symptoms of ischemia vary, as they can occur anywhere in the body and depend on the degree to which blood flow is interrupted. [4] For example, clinical manifestations of acute limb ischemia (which can be summarized as the "six P's") include pain, pallor, pulseless, paresthesia, paralysis, and poikilothermia.
Reperfusion therapy is a medical treatment to restore blood flow, either through or around, blocked arteries, typically after a heart attack (myocardial infarction (MI)). Reperfusion therapy includes drugs and surgery .
Pain distal to the fistula. Symptoms are graded by their severity: [3] Grade 0: No symptoms of steal; Grade 1: Mild - cool extremity, improvement in hand pulse with access occlusion; Grade 2: Moderate - Ischemic symptoms during dialysis; Grade 3: Severe - Ischemic hand pain outside of dialysis; Ulcers or gangrene of the fingers
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