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Warfarin interacts with many commonly used drugs, and the metabolism of warfarin varies greatly between patients. [27] Some foods have also been reported to interact with warfarin. [27] Apart from the metabolic interactions, highly protein bound drugs can displace warfarin from serum albumin and cause an increase in the INR. [63]
Direct factor Xa inhibitors can be considered as an alternative to warfarin, particularly if a person is on several other medications that interact with warfarin, or if attending medical appointments and laboratory monitoring becomes difficult. [8]
They are categorised as "first-generation" anticoagulants, and have similar effects as warfarin. They have been largely superseded by second-generation anticoagulants because warfarin-resistant rodents have become more common. [6] Anisindione, fluindione, and phenindione are oral anticoagulant medicines with actions similar to warfarin. However ...
Dabigatran is an oral direct thrombin inhibitor. Dabigatran (Pradaxa) was found to be noninferior to Warfarin in prevention of ischemic stroke, as well as intracranial hemorrhage risk and overall mortality for non-valvular atrial fibrillation according to the RE-LY trial. [9]
He also notes that watercress' high vitamin K content can interact with certain medications, especially blood thinners like warfarin (Coumadin). ... can affect how these medications work ...
For example, warfarin, a commonly-used anticoagulant drug in atrial fibrillation, is metabolised by an enzyme called CYP2C9. Phenytoin, a CYP2C9 inducer, would increase its activity and the rate of warfarin breakdown, thereby reducing its efficacy. [25] Patients should avoid the co-administration of warfarin and phenytoin.
It can be caused by certain drug interactions, as well as drinking alcohol while taking a medication like Lexapro. ... Blood thinners and anticoagulants, like warfarin, due to risk of abnormal ...
Some such interactions are clinically significant, [19] although most herbal remedies are not associated with drug interactions causing serious consequences. [20] Most catalogued herb-drug interactions are moderate in severity. [21] The most commonly implicated conventional drugs in herb-drug interactions are warfarin, insulin, aspirin, digoxin ...
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