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Normal doses, 800–2000 IU per day, are safe in pregnancy. [5] Cholecalciferol was first described in 1936. [13] It is on the World Health Organization's List of Essential Medicines. [14] In 2022, it was the 62nd most commonly prescribed medication in the United States, with more than 10 million prescriptions.
Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [ 3 ] to prevent and treat vitamin D deficiency [ 4 ] due to poor absorption by the intestines or liver disease . [ 5 ]
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
Serum 25(OH)D concentration is used as a biomarker for vitamin D deficiency. Units of measurement are either ng/mL or nmol/L, with one ng/mL equal to 2.5 nmol/L. There is not a consensus on defining vitamin D deficiency, insufficiency, sufficiency, or optimal for all aspects of health. [20]
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