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Vasculitic neuropathy is a peripheral neuropathic disease. [ 1 ] [ 2 ] [ 3 ] In a vasculitic neuropathy there is damage to the vessels that supply blood to the nerves . [ 1 ] [ 2 ] [ 3 ] It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS).
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
The characteristics are typical of demyelinating neuropathy with antimyelin-associated glycoprotein (MAG) antibodies; however, anti-MAG neuropathy is not included in the CIDP criteria according to the EFNS/PNS criteria, primarily due to the presence of a particular antibody and a different response to treatment.
A decrease in blood flow through the vasa nervorum has been implicated in the development of diabetic neuropathy. Arteritis of the vasa nervorum leads to mononeuritis multiplex or polyneuropathy. [3] Occlusion of vasa nervorum at the level of the epineurial arterioles leads to ischemia of nerves, leading to vasculitic neuropathy.
Non-systemic vasculitic neuropathy (NSVN) [1] Hepatitis C-related cryoglobulinemia neuropathy (CRYOVASC) [1] Hepatitis B-associated PAN [1] Diabetic lumbosacral radiculoplexus neuropathy (DLRPN) [1] Non-diabetic lumbosacral radiculoplexus neuropathy (LRPN) [1] Diabetic cervical-radiculoplexus neuropathy (DCRPN) [1] Diabetic Cranio-Cervico ...
Treatment is targeted to the underlying cause. However, most vasculitis, in general, are treated with steroids (e.g., methylprednisolone) because the underlying cause of the vasculitis is due to hyperactive immunological damage. Immunosuppressants such as cyclophosphamide and azathioprine may also be given.
Hereditary neuropathy with liability to pressure palsy (HNPP) is a peripheral neuropathy, a condition that affects the nerves. [4] Pressure on the nerves can cause tingling sensations, numbness, pain, weakness, muscle atrophy and even paralysis of the affected area. In normal individuals, these symptoms disappear quickly, but in sufferers of ...
Since the complications mimic foot ulcers caused by diabetic neuropathy, the treatment for foot ulcers and infections can follow the guidelines given for diabetic foot care which starts with early and accurate counseling of patients about risk factors for developing foot ulcerations.
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