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Physicians have described the successful use of a variety of discontinued antiprotozoals in treatment of Blastocystis infection. Emetine was reported as successful in cases in early 20th century with British soldiers who contracted Blastocystis infection while serving in Egypt. [2]
Blastocystis hominis is a single-celled eukaryotic organism that inhabits the gastrointestinal tract of humans and various animals. [1] This stramenopile exhibits significant genetic diversity and has become an organism of increasing scientific interest due to its widespread distribution and controversial role in human health. [ 2 ]
Blastocystis is a genus of single-celled parasites belonging to the Stramenopiles that includes algae, diatoms, and water molds.There are several species, living in the gastrointestinal tracts of species as diverse as humans, farm animals, birds, rodents, reptiles, amphibians, fish, and cockroaches. [2]
Blastocystis is a single-celled protozoan which infects the large intestine. Physicians report that patients with infection show symptoms of abdominal pain, constipation, and diarrhea. [54] [55] [56] One study found that 43% of IBS patients were infected with Blastocystis versus 7% of controls. [49]
Irritable bowel syndrome (IBS) is associated with the bacteria enteroaggregative Escherichia coli [68] and Mycobacterium avium subspecies paratuberculosis, [69] the protozoan parasite Giardia lamblia, [70] and pathogenic strains of the protozoan parasite Blastocystis hominis. [71]
William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher best known for his early contributions to the study of cancer immunotherapy, specifically causing infection as a way to fight cancer, a practice used as far back as 1550 BC. [1]
Protozoal infections can cause symptoms that mirror specific IBS subtypes, [51] e.g., infection by certain substypes of Blastocystis hominis (blastocystosis). [52] [53] Many people regard these organisms as incidental findings, and unrelated to symptoms of IBS.
Endolimax is a genus of amoebozoa [1] that are found in the intestines of various animals, including the species E. nana found in humans. Originally thought to be non-pathogenic, studies suggest it can cause intermittent or chronic diarrhea.