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Salicylate intolerance is a form of food intolerance or of drug intolerance. Salicylate sensitivity is a pharmacological reaction, not a true IgE-mediated allergy. However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions.
Oral allergy syndrome (OAS) or pollen-food allergy syndrome (PFAS) is a type of allergy classified by a cluster of allergic reactions in the mouth and throat in response to eating certain (usually fresh) fruits, nuts, and vegetables. It typically develops in adults with hay fever. [1] It is not usually serious. [2]
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
The test has a sensitivity of 94% and a specificity of 74% for identifying patients whose salicylate concentrations are greater than 30 mg per decilitre (2.17 mmol/L). [1] False positive concentrations (2.8 to 14.3 mg per decilitre) have been reported to occur in neonates with hyperbilirubinemia , premature neonates, and children who are ...
Beginning in 1980, the CDC cautioned physicians and parents about the association between Reye syndrome and the use of salicylates in children and teenagers with chickenpox or virus-like illnesses. In 1982, the U.S. Surgeon General issued an advisory, and in 1986, the Food and Drug Administration required a Reye syndrome-related warning label ...
With large salicylate doses, the kinetics switch from first-order to zero-order, as metabolic pathways become saturated and renal excretion becomes increasingly important. [ 64 ] Salicylates are excreted mainly by the kidneys as salicyluric acid (75%), free salicylic acid (10%), salicylic phenol (10%), and acyl glucuronides (5%), gentisic acid ...
Meat, poultry, fish, eggs, dairy products, sugar, breads and cereals have low salicylate content. [19] [52] Some people with sensitivity to dietary salicylates may have symptoms of allergic reaction, such as bronchial asthma, rhinitis, gastrointestinal disorders, or diarrhea, so may need to adopt a low-salicylate diet. [19]
Side effects include skin irritation, and salicylate poisoning. [2] Salicylate poisoning tends to only occur when applied to a large area and in children. [2] Use is thus not recommended in children less than two years old. [2] It comes in a number of different strengths. [3] It is on the World Health Organization's List of Essential Medicines.