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  2. Midazolam - Wikipedia

    en.wikipedia.org/wiki/Midazolam

    Onset of action: Within 5 min (IV), 15 min (IM), ... Midazolam, sold under the brand ... This incident was the first time a drug company successfully, ...

  3. Palliative sedation - Wikipedia

    en.wikipedia.org/wiki/Palliative_sedation

    Among all benzodiazepine agents, midazolam (Versed) is the most frequently used medication for palliative sedation for its rapid onset and short duration of action. The main indications for midazolam in palliative sedation are to control delirium and alleviate breathing difficulties so as to minimize distress and prevent exacerbation of these ...

  4. General anaesthesia - Wikipedia

    en.wikipedia.org/wiki/General_anaesthesia

    The most commonly utilized benzodiazepine is Midazolam, which is characterized by a rapid onset and short duration. Midazolam is effective in reducing preoperative anxiety, including separation anxiety in children. [28] It also provides mild sedation, sympathicolysis, and anterograde amnesia. [6]

  5. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...

  6. Rapid sequence induction - Wikipedia

    en.wikipedia.org/wiki/Rapid_sequence_induction

    It has slow onset of action when used alone, but the onset can be improved when using together with an opioid. [9] However, for those with hypotension, midazolam can further reduce the blood pressure and has cardiac depressive effects. [14] Therefore, dose reduction is required for the elderly, and for those with heart and liver failure. [8]

  7. Ro48-6791 - Wikipedia

    en.wikipedia.org/wiki/Ro48-6791

    Ro48-6791 has properties similar to those of midazolam, being water-soluble, with a fast onset and short duration of action. It is 4-6x more potent than midazolam, [ 2 ] and slightly shorter acting, [ 3 ] and produces similar side effects such as sedation and amnesia.

  8. Remimazolam - Wikipedia

    en.wikipedia.org/wiki/Remimazolam

    Remimazolam was found to have both a more rapid onset and a shorter duration than midazolam, and human clinical trials showed a faster recovery time and predictable, consistent pharmacokinetics, suggesting some advantages over existing drugs for these applications. [7] [8]

  9. Etomidate - Wikipedia

    en.wikipedia.org/wiki/Etomidate

    At the typical dose, anesthesia is induced for the duration of about 5–10 minutes, though the half-life of drug metabolism is about 75 minutes, because etomidate is redistributed from the plasma to other tissues. Onset of action: 30–60 seconds; Peak effect: 1 minute; Duration: 3–5 minutes; terminated by redistribution