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Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. [ 36 ] Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use [ 37 ] [ 38 ] these side effects usually disappear after ...
Lamotrigine is metabolized predominantly by glucuronic acid conjugation. Its major metabolite is an inactive 2-n-glucuronide conjugate. [82] Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half ...
Calcium has been shown to block sodium channels [2] which explains the effects of hypercalcemia and hypocalcemia.; Lamotrigine is known to block sodium channels but it is not known whether it is extracellular or intracellular.
Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. [1] It is an active metabolite of oxcarbazepine . [ 1 ] [ 2 ] In addition, an enantiomer of licarbazepine, eslicarbazepine (( S )-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate .
Switching directly is usually only a safe option for switching between certain SSRIs and SNRIs with short half-lives, as these medications are less likely to cause drug interactions or unwanted ...
Similarly, children exposed lamotrigine or phenytoin in the womb do not seem to differ in their skills compared to those who were exposed to carbamazepine. [ 96 ] There is inadequate evidence to determine if newborns of women with epilepsy taking anticonvulsants have a substantially increased risk of hemorrhagic disease of the newborn .
Bipolar disorder is uncommon in older patients, with a measured lifetime prevalence of 1% in over 60s and a 12-month prevalence of 0.1–0.5% in people over 65. Despite this, it is overrepresented in psychiatric admissions, making up 4–8% of inpatient admission to aged care psychiatry units, and the incidence of mood disorders is increasing ...
Retigabine is quickly absorbed, and reaches maximum plasma concentrations between half an hour and 2 hours after a single oral dose. It has a moderately high oral bioavailability (50–60%), a high volume of distribution (6.2 L/kg), and a terminal half-life of 8 to 11 hours. [14] Retigabine requires thrice-daily dosing due to its short half-life.
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