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Pregnancy-specific beta-1-glycoprotein is a major product of the syncytiotrophoblast in the placenta, reaching concentrations of 100 to 290 mg/L at term in the serum of pregnant women. [ 3 ] [ 12 ] PSGs are synthesized through a gene's coding for a specific protein.
Pregnancy-specific beta-1-glycoprotein 1 encoded by the PSG1 gene. Produced in high quantity during pregnancy. CD68: 110 kDa highly glycosylated transmembrane protein which is mainly located in lysosomes.
β 2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. [5] One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β 2-GP1 both undergo large changes in structure. [6]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein+beta-1,3-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t
In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β 2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. [ 1 ]
1 Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. 2 Function
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene. [5] [6]There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides.
The common core 1 O-glycan structure Gal-beta-1-3GalNAc-R is a precursor for many extended mucin-type O-glycan structures in animal cell surface and secreted glycoproteins. Core 1 is synthesized by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R by core 1 beta-3-galactosyltransferase (C1GALT1). [2] C1GALT1 is associated with the T-Tn ...