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A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
Aerobic respiration requires oxygen (O 2) in order to create ATP. Although carbohydrates, fats and proteins are consumed as reactants, aerobic respiration is the preferred method of pyruvate production in glycolysis, and requires pyruvate be transported the mitochondria in order to be oxidized by the citric acid cycle.
Metabolic pathways can be targeted for clinically therapeutic uses. Within the mitochondrial metabolic network, for instance, there are various pathways that can be targeted by compounds to prevent cancer cell proliferation. [17] One such pathway is oxidative phosphorylation (OXPHOS) within the electron transport chain (ETC). Various inhibitors ...
Bioenergetics is a field in biochemistry and cell biology that concerns energy flow through living systems. [1] This is an active area of biological research that includes the study of the transformation of energy in living organisms and the study of thousands of different cellular processes such as cellular respiration and the many other metabolic and enzymatic processes that lead to ...
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
Mutually, post-translational alterations of mitochondrial apparatus and the development of transmembrane contact sites among mitochondria and other structures, which both have the potential to link signals from diverse routes that affect mitochondrial membrane dynamics substantially, [36] Mitochondria are wrapped by two membranes: an inner ...
Its fully reduced state, which consists of a reduced Fe 2+ at the cytochrome a 3 heme group and a reduced Cu B + binuclear center, is considered the inactive or resting state of the enzyme. [ 19 ] Cyanide , azide , and carbon monoxide [ 20 ] all bind to cytochrome c oxidase, inhibiting the protein from functioning and leading to the chemical ...
In yeast mitochondria lacking cardiolipin, the number of enzymes forming respiratory supercomplexes was significantly reduced. [ 17 ] [ 18 ] According to Wenz et al. (2009), cardiolipin stabilizes the supercomplex formation by neutralizing the charges of lysine residues in the interaction domain of Complex III with Complex IV. [ 19 ]