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Although benzodiazepines can put people to sleep, while asleep, the drugs disrupt sleep architecture, decreasing sleep time, delayed and decreased REM sleep, increased alpha and beta activity, decreased K complexes and delta activity, and decreased deep slow-wave sleep (i.e., NREM stages 3 and 4, the most restorative part of sleep for both ...
Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. [132] Clonazepam plasma levels are very unreliable amongst patients. Plasma levels of clonazepam can vary as much as tenfold between different patients. [133]
The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms. [citation needed] For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.
[72] [73] Restless legs syndrome can be treated using clonazepam as a third line treatment option as the use of clonazepam is still investigational. [ 74 ] [ 75 ] Benzodiazepines are sometimes used for obsessive–compulsive disorder (OCD), although they are generally believed ineffective for this indication.
At the very least, the best dogs for seniors will be affectionate, obedient and low maintenance. How Dogs Can Benefit Seniors Adopting a dog may be the best decision a senior citizen can make. We ...
Tablets can be divided to provide a more accurate dose, but if you have a little dog, 10 pounds or less, I would suggest you buy the liquid form because it will be more accurate to dose the dog ...
"The mean age at death (all breeds, all causes) was 11 years and 1 month, but in dogs dying of natural causes it was 12 years and 8 months. Only 8 percent of dogs lived beyond 15, and 64 percent of dogs died of disease or were euthanized as a result of disease. Nearly 16 percent of deaths were attributed to cancer, twice as many as to heart ...
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