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Endothelin functions through activation of two G protein-coupled receptors, endothelin A and endothelin B receptor (ETA and ETB, respectively). [2] These two subtypes of endothelin receptor are distinguished in the laboratory by the order of their affinity for the three endothelin peptides: the ETA receptor is selective for ET-1, whereas the ETB receptor has the same affinity for all three ET ...
Widely distributed in the body, receptors for endothelin are present in blood vessels and cells of the brain, choroid plexus and peripheral nerves.When applied directly to the brain of rats in picomolar quantities as an experimental model of stroke, endothelin-1 caused severe metabolic stimulation and seizures with substantial decreases in blood flow to the same brain regions, both effects ...
Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET 1, ET 2, and ET 3. A splice variant, named SVR, has been described; the sequence of the ETB-SVR receptor is identical to ETRB ...
13614 Ensembl ENSG00000078401 ENSMUSG00000021367 UniProt P05305 P22387 RefSeq (mRNA) NM_001168319 NM_001955 NM_010104 RefSeq (protein) NP_001161791 NP_001946 NP_001161791 NP_001946 NP_034234 Location (UCSC) Chr 6: 12.29 – 12.3 Mb Chr 13: 42.45 – 42.46 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent ...
1909 13617 Ensembl ENSG00000151617 ENSMUSG00000031616 UniProt P25101 Q61614 RefSeq (mRNA) NM_001166055 NM_001256283 NM_001957 NM_001354797 NM_010332 RefSeq (protein) NP_001159527 NP_001948 NP_001341726 NP_034462 Location (UCSC) Chr 4: 147.48 – 147.54 Mb Chr 8: 78.39 – 78.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endothelin receptor type A, also known as ET A, is a human ...
Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. [5] The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein.
Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team [ 5 ] and belongs to a family of three endothelin peptide isoforms ( ET-1 , ET-2 , ET-3 ), which constrict blood vessels.
Vascular endothelial growth factor (VEGF, / v ɛ dʒ ˈ ɛ f /), originally known as vascular permeability factor (VPF), [1] is a signal protein produced by many cells that stimulates the formation of blood vessels.