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The procedure enforces compliance with the program's end-user license agreement by transmitting information about both the product key used to install the program and the user's computer hardware to Microsoft, inhibiting or completely preventing the use of the program until the validity of its license is confirmed. [1]
A product key is required to proceed and use Windows 95. In one form, product activation refers to a method invented by Ric Richardson and patented (U.S. patent 5,490,216) by Uniloc where a software application hashes hardware serial numbers and an ID number specific to the product's license (a product key) to
[9] [10] Cdh1 contains multiple phosphorylation sites for the kinase cdc28. When cdh1 is hyperphosphorytaled, the association of cdh1 to the APC/c is blocked, thus leading to the inactive form of cdh1. Activation can be induced by dephosphorylation through the phosphatase cdc14, which leads to the binding of cdh1 to the APC/c. [9] [11]
The VP64-p65-Rta, or VPR, dCas9 activator was created by modifying an existing dCas9 activator, in which a Vp64 transcriptional activator is joined to the C terminus of dCas9. [1] In the dCas9-VPR protein, the transcription factors p65 and Rta are added to the C terminus of dCas9-Vp64.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
[1] [2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase. [1] [2] The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. [3] [4] In Escherichia coli, CRP can regulate the transcription of more than 100 genes. [5]
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2]
Catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) is a trans-acting transcriptional activator that exists as a homodimer in solution. Each subunit of CAP is composed of a ligand -binding domain at the N-terminus (CAP N , residues 1–138) and a DNA-binding domain at the C-terminus (DBD, residues 139–209).