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Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication.As a medication, it is mainly used to treat methemoglobinemia by chemically reducing the ferric iron in hemoglobin to ferrous iron.
According to the book The Ultimate Guide to Methylene Blue by Mark Slogan, the author claims that the medicine has cause to give: “Remarkable Hope for Depression, COVID, AIDS & other Viruses ...
The synthetic dye methylene blue, containing the structure, was described in 1876. Many water-soluble phenothiazine derivatives, such as methylene blue, methylene green, thionine, and others, can be electropolymerized into conductive polymers used as electrocatalysts for NADH oxidation in enzymatic biosensors and biofuel cells. [10] [11] [12]
It is the only known drug to cure both relapsing malaria infections and acute cases. The mechanism of action is not fully understood but it is thought to block oxidative metabolism in Plasmodia. It can also be combined with methylene blue. [16] For the prevention of relapse in P. vivax and P. ovale 0.15 mg/kg should be given for 14 days.
Allergic-like reactions and methemoglobinemia have been documented after the use of methylene blue dye in chromopertubation. [9] These reported symptoms vary from blue discoloration of body fluids to anaphylactic shock. [10] Methemoglobinemia is a blood disorder that can potentially result in various levels of cyanosis. [11]
New methylene blue (also NMB) [clarify] is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.
The aqueous solution in the classical reaction contains glucose, sodium hydroxide and methylene blue. [14] In the first step an acyloin of glucose is formed. The next step is a redox reaction of the acyloin with methylene blue in which the glucose is oxidized to diketone in alkaline solution [6] and methylene blue is reduced to colorless leucomethylene blue.
The most effective treatment for severe (grade III–IV) encephalopathy is an intravenous solution of methylene blue, which appears to shorten the duration of encephalopathy; the exact mechanism of action of methylene blue is unclear. In some cases, methylene blue may be used as a prophylaxis before further doses of ifosfamide are administered.
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