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Recurrent corneal erosion (RCE) is a disorder of the eyes characterized by the failure of the cornea's outermost layer of epithelial cells to attach to the underlying basement membrane (Bowman's layer). The condition is excruciatingly painful because the loss of these cells results in the exposure of sensitive corneal nerves.
Doxycycline, at subantimicrobial doses, inhibits MMP activity, and has been used in various experimental systems for this purpose, such as for recalcitrant recurrent corneal erosions. It is used clinically for the treatment of periodontal disease and is the only MMP inhibitor that is widely available clinically.
Findings are variable and can change with time. While the disorder is usually asymptomatic, up to 10% of patients may have recurrent corneal erosions, usually beginning after age 30; conversely, 50% of patients presenting with idiopathic recurrent erosions have evidence of this dystrophy. [5]
Punctate epithelial erosions may be seen with different disorders: Rosacea; Dry-eye syndrome; Blepharitis; Acute bacterial conjunctivitis [1] Trauma; Exposure keratopathy from poor eyelid closure; Ultraviolet or chemical burn; Contact lens-related disorder such as toxicity or tight lens syndrome; Trichiasis; Entropion or ectropion; Floppy ...
Recurrent corneal erosions may occur. The hallmark of Schnyder corneal dystrophy is the accumulation of crystals within the corneal stroma which cause corneal clouding typically in a ring-shaped fashion. [citation needed] Posterior corneal dystrophies – Fuchs corneal dystrophy presents during the fifth or sixth decade of life. The ...
Long-term contact lens use can lead to alterations in corneal thickness, stromal thickness, curvature, corneal sensitivity, cell density, and epithelial oxygen uptake. . Other structural changes may include the formation of epithelial vacuoles and microcysts (containing cellular debris), corneal neovascularization, as well as the emergence of polymegethism in the corneal endoth
These recurrent painful corneal epithelial erosions often begin as early as 1 year of age. [1] With time, the corneal changes progress into opacities in Bowman's layer, which gradually becomes more irregular and more dense. [1] Significant vision loss may occur. [2] However, vascularization of the cornea is not present. [2]
Recurrent corneal erosions may precede the corneal opacities and even appear in individuals lacking recognizable stromal disease. Amyloid deposits are found throughout the corneal stroma. Linear and other shaped opaque areas accumulate particularly within the central corneal stroma, while the peripheral cornea remains relatively transparent.