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BLAT connects each homologous area between two sequences into a single larger alignment, in contrast to BLAST which returns each homologous area as a separate local alignment. The result of BLAST is a list of exons with each alignment extending just past the end of the exon.
While BLAST does a linear search, BLAT relies on k-mer indexing the database, and can thus often find seeds faster. [23] Another software alternative similar to BLAT is PatternHunter . Advances in sequencing technology in the late 2000s has made searching for very similar nucleotide matches an important problem.
In cell biology, precursor cells—also called blast cells—are partially differentiated, or intermediate, and are sometimes referred to as progenitor cells. A precursor cell is a stem cell with the capacity to differentiate into only one cell type, meaning they are unipotent stem cells .
Biology is the scientific study of life. [ 1 ] [ 2 ] [ 3 ] It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. [ 1 ] [ 2 ] [ 3 ] For instance, all organisms are composed of at least one cell that processes hereditary information encoded in genes , which can be transmitted ...
It makes use of the BLAST [5] algorithm to identify similar sequences to then transfers existing functional annotation from yet characterised sequences to the novel one. The functional information is represented via the Gene Ontology (GO), a controlled vocabulary of functional attributes.
The BLAST family of search methods provides a number of algorithms optimized for particular types of queries, such as searching for distantly related sequence matches. BLAST was developed to provide a faster alternative to FASTA without sacrificing much accuracy; like FASTA, BLAST uses a word search of length k , but evaluates only the most ...
Comparison of monoblast, promonocyte and monocyte. A typical monoblast is about 12 to 20 μm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure.
The division of blastomeres from the zygote allows a single fertile cell to continue to cleave and differentiate until a blastocyst forms. The differentiation of the blastomere allows for the development of two distinct cell populations: the inner cell mass, which becomes the precursor to the embryo, and the trophectoderm, which becomes the precursor to the placenta.