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Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
Consider the sunburn, a deterministic effect: [4] when exposed to bright sunlight for only ten minutes [5] at a high UV Index, that is to say a high average dose rate, [6] the skin can turn red and painful. The same total amount of energy from indirect sunlight spread out over several years - a low average dose rate - would not cause a sunburn ...
Pulmonary drug delivery is a route of administration in which patients use an inhaler to inhale their medications and drugs are absorbed into the bloodstream via the lung mucous membrane. This technique is most commonly used in the treatment of lung diseases, for example, asthma and chronic obstructive pulmonary disease (COPD) .
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So, the maintenance dose of foosporin is 100 milligrams (100 mg) per day—just enough to offset the amount cleared. Suppose a patient just started taking 100 mg of foosporin every day. On the first day, they'd have 100 mg in their system; their body would clear 10 mg, leaving 90 mg.
These results showed a low survival rate in these canines, and further demonstrated the basis of many surgical complications including pleural effusions, ascites, and thrombosis. [12] In 1964, Haller introduced the bidirectional superior cavo-pulmonary shunt in 50 dogs with a superior vena cava to right pulmonary artery anastomosis with ...
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Boxer cardiomyopathy (also known as "Boxer arrhythmogenic right ventricular cardiomyopathy") is a disease of the myocardium primarily affecting Boxer dogs.It is characterized by the development of ventricular tachyarrhythmias, resulting in syncope and sudden cardiac death.