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A neoplasm (/ ˈ n iː oʊ p l æ z əm, ˈ n iː ə-/) [1] [2] is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is ...
Such loss of structural differentiation is especially seen in most, but not all, malignant neoplasms. [2] Sometimes, the term also includes an increased capacity for multiplication. [3] Lack of differentiation is considered a hallmark of aggressive malignancies (for example, it differentiates leiomyosarcomas from leiomyomas).
It is the result of increased cell mitosis or division (also referred to as cell proliferation). The two types of physiologic hyperplasia are compensatory and hormonal. Compensatory hyperplasia permits tissue and organ regeneration. It is common in epithelial cells of the epidermis and intestine, liver hepatocytes, bone marrow cells, and ...
The primary result of mitosis and cytokinesis is the transfer of a parent cell's genome into two daughter cells. The genome is composed of a number of chromosomes—complexes of tightly coiled DNA that contain genetic information vital for proper cell function. [32]
The proportion of cells within a sample which are undergoing mitosis at the time of observation, typically expressed as a percentage or as a value between 0 and 1. The number of cells dividing by mitosis at any given time can vary widely depending on organism, tissue, developmental stage, and culture media, among other factors. [2] mitotic ...
Cancer is also euphemised as "the C-word"; [232] [233] [234] Macmillan Cancer Support uses the term to try to lessen the fear around the disease. [235] In Nigeria, one local name for cancer translates into English as "the disease that cannot be cured". [ 236 ]
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. [1] Cell division is a normal process used by the body for growth and repair.
Diagram showing events that can lead to mitotic catastrophe and the potential outcomes. One usage of the term mitotic catastrophe is to describe an oncosuppressive mechanism (i.e. a mechanism to prevent the proliferation of cancerous cells and the development of tumors) that occurs when cells undergo and detect a defective mitosis has occurred. [5]