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Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise.
Plaques in the walls of the coronary arteries can rupture, resulting in occlusion of the artery and deprivation of blood flow and oxygen to the heart muscle, resulting in cardiac cell death. [9] This is known as myocardial infarction. [9] A heart attack can cause arrhythmias, as well as permanent damage to the heart muscle. [25]
This is typically secondary to stroke, injury, or cardiac arrest due to heart attack. Most ischemic neurons that die do so due to the activation of chemicals produced during and after ischemia. [2] The ischemic cascade usually goes on for two to three hours but can last for days, even after normal blood flow returns. [3]
The heart muscle may become inflamed in a condition called myocarditis, [46] most commonly caused by a viral infection [47] but sometimes caused by the body's own immune system. [48] Heart muscle can also be damaged by drugs such as alcohol, long standing high blood pressure or hypertension, or persistent abnormal heart racing. [49]
The word infarction means that some area of tissue has died due to a lack of blood flow, and therefore a lack of oxygen. “Myo” refers to the muscle, and “cardial” refers to the heart tissue. So with a heart attack, or MI, you have death of heart muscle cells because of a lack in blood flow, a process called necrosis.
About 12.2 million new strokes are diagnosed each year. One in four stroke survivors will experience another stroke. Stroke survivors are at an increased risk of developing major heart issues ...
Cardiac ischemia may be asymptomatic or may cause chest pain, known as angina pectoris. It occurs when the heart muscle, or myocardium, receives insufficient blood flow. [10] This most frequently results from atherosclerosis, which is the long-term accumulation of cholesterol-rich plaques in the coronary arteries.
Subsequent to this is a period of "myocardial stunning," in which reversible ischemic damage is taking place. At approximately 30 minutes after the onset of total ischemia the damage becomes irreversible, [6] thereby ending the phase of myocardial stunning. The generation of oxygen-derived [free radicals] during the initial period of ...
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