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Tamoxifen has been found to decrease insulin-like growth factor 1 (IGF-1) levels by 17 to 38% in women and men. [85] Suppression of IGF-1 production in the liver is a well-known action of estrogens and SERMs. [85] A 10 mg/day dosage of tamoxifen is nearly as effective as a 20 mg/day dosage in suppressing IGF-1 levels. [5]
Dutasteride is also used in the treatment of male pattern hair loss and appears to have better effectiveness than finasteride for the condition. [27] [28] [29] While used off-label for male pattern hair loss in most of the world, dutasteride is specifically approved for this indication in South Korea and Japan. [30] [31]
Tamoxifen is a pure antiestrogenic trans-isomer and has differential actions at estrogen target tissues throughout the body. Tamoxifen is selectively antiestrogenic in the breast but estrogen-like in bones and endometrial cancer. [24] Tamoxifen undergo phase I metabolism in the liver by microsomal cytochrome P450 (CYP) enzymes.
Let’s talk 5mg finasteride vs 1mg—two different doses, one powerful hair loss treatment. Finasteride is the active ingredient in Propecia®, an oral medication that’s clinically-proven to ...
There are several causes of hair loss in men under 25 (including teens). Potential causes of hair loss for the 20-and-under set include: Male androgenetic alopecia (male pattern baldness) Alopecia ...
Notes: Prevention of breast symptoms—specifically gynecomastia and breast pain—induced by 150 mg/day bicalutamide monotherapy with tamoxifen in 282 men with prostate cancer. Bicalutamide and tamoxifen were initiated at the same time (0 months). Estradiol levels were in the range of about 22 to 47 pg/mL in the treated group. [1] Sources: [2] [1]
N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). [1] [2] N-Desmethyltamoxifen is further metabolized into endoxifen (4-hydroxy-N-desmethyltamoxifen), which is thought to be the major active form of tamoxifen in the body.
Alopecia totalis is the loss of all hair on the head and face.Its causes are unclear, but believed to be autoimmune.Research suggests there may be a genetic component linked to developing alopecia totalis; the presence of DRB1*0401 and DQB1*0301, both of which are human leukocyte antigens (HLA), were found to be associated with long-standing alopecia totalis.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261