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Recent development in experimental identification of RNA-binding proteins has extended the number of RNA-binding proteins significantly [32] [33] [34] RNA-binding protein Sam68 controls the spatial and temporal compartmentalization of RNA metabolism to attain proper synaptic function in dendrites.
100043257 Ensembl ENSG00000102317 n/a UniProt P98179 n/a RefSeq (mRNA) NM_001017430 NM_001017431 NM_006743 XM_036156140 RefSeq (protein) NP_006734 n/a Location (UCSC) Chr X: 48.57 – 48.58 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene. Function This gene is a member of the glycine -rich RNA ...
After being produced, the stability and distribution of the different transcripts is regulated (post-transcriptional regulation) by means of RNA binding protein (RBP) that control the various steps and rates controlling events such as alternative splicing, nuclear degradation (), processing, nuclear export (three alternative pathways), sequestration in P-bodies for storage or degradation and ...
CD44 proteins belong to a family of cell surface adhesion molecules that are involved in both cell-cell and cell-matrix communications. [7] CRD-BP binds to and protects CD44 RNA which shows increased expression in cancers. [6] CRD-BP plays a role in the localization of β-actin mRNA by binding to the localization element in the 3'UTR region. [8]
The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [4]
CPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. [1] CPEB is present at postsynaptic sites and dendrites where it stimulates polyadenylation and translation in response to synaptic activity. [ 2 ]
The FET protein family (also known as the TET protein family) [1] consists of three similarly structured and functioning proteins. [2] They and the genes in the FET gene family which encode them (i.e. form the pre-messenger RNAs that are converted to the messenger RNAs responsible for their production) are: [2] [3] 1) the EWSR1 protein encoded by the EWSR1 gene (also termed the Ewing sarcoma ...
Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA.The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. [2]
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