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  2. Kava - Wikipedia

    en.wikipedia.org/wiki/Kava

    Traditionally, only noble kava cultivars have been consumed, as they are accepted as safe and produce desired effects. [63] The specific effects of various noble kavas depend on various factors, such as the cultivar used (and the related specific composition of kavalactones), age of the plant, and method of consumption. [62]

  3. Kavalactone - Wikipedia

    en.wikipedia.org/wiki/Kavalactone

    Kavalactones are a class of lactone compounds found in kava roots and Alpinia zerumbet (shell ginger). [1] and in several Gymnopilus, Phellinus and Inonotus fungi. [2] Some kavalactones are bioactive. They are responsible for the psychoactive, analgesic, euphoric and sedative effects of kava. [3] [4]

  4. List of herbs with known adverse effects - Wikipedia

    en.wikipedia.org/wiki/List_of_herbs_with_known...

    Kava: kava-kava Piper methysticum: Sedatives, sleeping pills, antipsychotics, alcohol [15] Milkvetch: Astragalus: Astragalus may interact with medications that suppress the immune system, such as cyclophosphamide. [24] It may also affect blood sugar levels and blood pressure. Pineapple enzyme Ananas comosus: Bromelain

  5. Kavain - Wikipedia

    en.wikipedia.org/wiki/Kavain

    Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels. [1] How this effect is mediated, and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system, is unknown.

  6. Mitragyna speciosa - Wikipedia

    en.wikipedia.org/wiki/Mitragyna_speciosa

    Mitragyna speciosa is a tropical evergreen tree of the Rubiaceae family (coffee family) native to Southeast Asia. [3] It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, [4] where its leaves, known as kratom, have been used in herbal medicine since at least the 19th century. [5]

  7. Yangonin - Wikipedia

    en.wikipedia.org/wiki/Yangonin

    The CB 1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human psychopharmacology of the traditional kava drink and the anxiolytic preparations obtained from the kava plant. [2] Like other kavalactones, yangonin has been found to potentiate GABA A receptors. [3]

  8. 6 Potential Long-Term Effects of Ozempic - AOL

    www.aol.com/6-potential-long-term-effects...

    Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease, diabetic retinopathy, and an increased heart rate. Semaglutide ...

  9. Methysticin - Wikipedia

    en.wikipedia.org/wiki/Methysticin

    Research suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity. [2] Additionally, methysticin has been shown to potentiate GABA A receptor activity, contributing to the overall anxiolytic profile of the kava plant.