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Intravenous sodium bicarbonate, also known as sodium hydrogen carbonate, is a medication primarily used to treat severe metabolic acidosis. [2] For this purpose it is generally only used when the pH is less than 7.1 and when the underlying cause is either diarrhea , vomiting , or the kidneys . [ 3 ]
It can substitute for baking soda (sodium bicarbonate) for those with a low-sodium diet, [4] and it is an ingredient in low-sodium baking powders. [5] [6] As an inexpensive, nontoxic base, it is widely used in diverse application to regulate pH or as a reagent. Examples include as buffering agent in medications, an additive in winemaking.
[1] [2] Hyperkalemia can cause an abnormal heart rhythm which can result in cardiac arrest and death. [1] [3] Common causes of hyperkalemia include kidney failure, hypoaldosteronism, and rhabdomyolysis. [1] A number of medications can also cause high blood potassium including spironolactone, NSAIDs, and angiotensin converting enzyme inhibitors. [1]
Overdoses cause hyperkalemia, which can lead to paresthesia, cardiac conduction blocks, fibrillation, arrhythmias, and sclerosis. [ 13 ] Because of the risk of small-bowel lesions, the US Food and Drug Administration (FDA) requires some potassium salts containing more than 99 mg (about 1.3 mEq) to be labeled with a warning, [ 14 ] while ...
Several approaches are used to treat hyperkalemia. [13] Other approved potassium binders in the United States include patiromer and sodium polystyrene sulfonate. [14] Hyperkalemia, particularly if severe, is a marker for an increased risk of death. [15] However, there is disagreement regarding whether a modestly elevated levels directly causes ...
Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. [1] In renal physiology, when blood is filtered by the kidney, the filtrate passes through the tubules of the nephron, allowing for exchange of salts, acid equivalents, and other solutes before it drains into the bladder as urine.
[3] [27] The final step in treatment is to calculate the patients free water deficit, and to replace it at a steady rate using a combination of oral or IV fluids. [3] [27] The rate of replacement of fluids varies depending on how long the patient has been hypernatremic. Lowering the sodium level too quickly can cause cerebral edema. [27]
The bicarbonate ion (hydrogencarbonate ion) is an anion with the empirical formula HCO − 3 and a molecular mass of 61.01 daltons; it consists of one central carbon atom surrounded by three oxygen atoms in a trigonal planar arrangement, with a hydrogen atom attached to one of the oxygens.