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Tocolytics are used in preterm labor, which refers to when a baby is born too early before 37 weeks of pregnancy. As preterm birth represents one of the leading causes of neonatal morbidity and mortality, the goal is to prevent neonatal morbidity and mortality through delaying delivery and increasing gestational age by gaining more time for other management strategies like corticosteroids ...
Terbutaline, sold under the brand names Bricanyl and Marex among others, is a β 2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours.
Ritodrine, sold under the brand name Yutopar, is a tocolytic drug used to stop premature labor. [2] [3] This drug has been removed from the US market, according to FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt. The drug acts as a selective β 2-adrenergic receptor agonist. [4]
Salbutamol and terbutaline are also both available in oral forms. [11] In addition, several of these medications are available in intravenous forms, including both salbutamol and terbutaline . It can be used in this form in severe cases of asthma , but it is more commonly used to suppress premature labor because it also relaxes uterine muscle ...
Uterotonics are used both to induce labor and to reduce postpartum hemorrhage. [1] Labor induction in the third trimester of pregnancy may be required due to medical necessity, or may be desired for social reasons. Generally, labor induction is indicated when the risk of carrying the pregnancy outweighs the risk of delivering. These reason ...
Getting an epidural during labor is linked with a decrease in severe maternal morbidity in the first few weeks after delivery. These severe complications can include heart attack, heart failure ...
Contraindications to a medication are any reasons to not use the drug. Prostaglandin E 2 (PGE 2) is used to induce labor and should not be used in people that are contraindicated to give birth vaginally or spontaneous labor. [25] PGE 2 should not be used in people with allergies to prostaglandins or any components in the drugs formulations. [4]
Uterine hyperstimulation or hypertonic uterine dysfunction is a potential complication of labor induction.This is displayed as Uterine tachysystole- the contraction frequency numbering more than five in a 10-minute time frame or as contractions exceeding more than two minutes in duration. [1]