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Meloxicam has been shown, especially at low therapeutic doses, to selectively inhibit COX-2 over COX-1. [9] Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid compared to plasma.
Studies of meloxicam 7.5 mg per day for 23 days find a level of gastric injury similar to that of a placebo, and for meloxicam 15 mg per day a level of injury lower than that of other NSAIDs; however, in clinical practice meloxicam can still cause some ulcer complications.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Generic hydrocodone/ibuprofen 7.5/200 mg. Hydrocodone/ibuprofen (), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain.
Co-dydramol is a non-proprietary name used to denote a particular compound analgesic, a combination of dihydrocodeine tartrate and paracetamol.Co-dydramol tablets are used for the relief of moderate pain.
Pharmacokinetic data; Bioavailability >80%: Metabolism: Hydrocodone: extensively liver, primarily CYP3A4; /Paracetamol: liver, CYP2E1 Elimination half-life: for hydrocodone: 228–294 mins (3.8–4.9 hrs); for paracetamol: 120–240 mins (2–4 hrs)
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. [2] It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. [3]
Treatment consists of combinations of crate confinement and courses of anti-inflammatory medications (steroids and non-steroidal anti-inflammatory drugs like carprofen and meloxicam), or chronic pain medications, like tramadol. Serious cases may require surgery to remove the troublesome disk contents. [41]