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[6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22] An analysis of cancer patients found that those who took tranquillisers or sleeping tablets had a substantially poorer quality of life on all measurements conducted, as well as a worse clinical picture ...
Like diazepam it has a long elimination half-life and long-acting active metabolites. Discontinuation of benzodiazepines or abrupt reduction of the dose, even after a relatively short course of treatment (two to four weeks), may result in two groups of symptoms, rebound and withdrawal .
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Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. [15] It is used to treat a range of conditions, including anxiety , seizures , alcohol withdrawal syndrome , muscle spasms , insomnia , and restless legs syndrome . [ 15 ]
Examples of preanesthetic agents are: Acepromazine [1]; atropine [1]; diazepam [1]; Scopolamine; Opioid analgesics, such as morphine, pethidine and buprenorphine.; These drugs are used before the administration of an anesthetic to improve patient comfort, reduce possible side effects such as Postanesthetic shivering, relieve pain, and increase the effectiveness of the anesthetic.
Avizafone [1] (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly. Avizafone is metabolised by enzymes in the blood to form the active drug diazepam. It is used mainly as an antidote to poisoning with organophosphate nerve agents. [2] [3] [4]
The consensus is to reduce dosage gradually over several weeks, e.g. 4 or more weeks for diazepam doses over 30 mg/day, [1] with the rate determined by the person's ability to tolerate symptoms. [120] The recommended reduction rates range from 50% of the initial dose every week or so, [121] to 10–25% of the daily dose every 2 weeks. [120]