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In 1971, Barry Pressman and Henry Burdick launched Nature Made, inspired by the belief that “there was a better alternative to long term health than prescription drugs.” [1] [2] The company joined the Council for Responsible Nutrition (CRN) in 1981. [2] Nature Made began operating as a brand of Pharmavite as of this date.
Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [3] to prevent and treat vitamin D deficiency [4] due to poor absorption by the intestines or liver disease. [5]
For example, CYP11A1, an enzyme chiefly known for its role in steroidogenesis, has been found to hydroxylate vitamin D3 at several positions, including C-20, C-22, and C-23, without cleaving the side chain. The resulting metabolites, such as 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3, act as inverse agonists for RORα and RORγ2.
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
The LD 50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. [ 51 ] [ 52 ] Kidneys and heart are target organs. [ 53 ] LD 50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. [ 54 ]
Trimix is a combination of three drugs: alprostadil, papaverine, and phentolamine. These medications work in combination to increase blood flow to the penis, resulting in an erection.
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