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Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Several forms of vitamin D exist, with the two major forms being vitamin D 2 or ergocalciferol, and vitamin D 3 or cholecalciferol. [1]The common-use term "vitamin D" refers to both D 2 and D 3, which were chemically characterized, respectively, in 1931 and 1935.
The LD 50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. [ 51 ] [ 52 ] Kidneys and heart are target organs. [ 53 ] LD 50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. [ 54 ]
In 1971, Barry Pressman and Henry Burdick launched Nature Made, inspired by the belief that “there was a better alternative to long term health than prescription drugs.” [1] [2] The company joined the Council for Responsible Nutrition (CRN) in 1981. [2] Nature Made began operating as a brand of Pharmavite as of this date.
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
The most prevalent side effects include nausea, mild sedation, fatigue, and dizziness. At higher dosages, there is an increased risk for restlessness, insomnia, and tremors. [6] Cariprazine was approved for medical use in the United States in September 2015. [12] It was approved as a generic medication in 2022, [13] but is covered by patents ...
7-DHC can be produced by animals and plants via different pathways. It is not produced by fungi in significant amounts. It is made by some algae, but the pathway is poorly understood. [11] Industrially, 7-DHC generally comes from lanolin, and is used to produce vitamin D3 by UV exposure. [12] Lichen (Cladonia rangiferina) is used to produce ...
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