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Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [3] to prevent and treat vitamin D deficiency [4] due to poor absorption by the intestines or liver disease. [5]
Nature Made is an American dietary supplement and vitamin brand founded in 1971 by Barry Pressman and Henry Burdick. [ 1 ] [ 2 ] Nature Made began operating as a brand of Pharmavite as of this date. [ when? ] [ 3 ] [ better source needed ] Parent company Pharmavite was acquired by Otsuka Pharmaceutical in 1989.
For example, CYP11A1, an enzyme chiefly known for its role in steroidogenesis, has been found to hydroxylate vitamin D3 at several positions, including C-20, C-22, and C-23, without cleaving the side chain. The resulting metabolites, such as 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3, act as inverse agonists for RORα and RORγ2.
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
The LD 50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. [ 51 ] [ 52 ] Kidneys and heart are target organs. [ 53 ] LD 50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. [ 54 ]
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
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