Search results
Results from the WOW.Com Content Network
The human Y chromosome is composed of about 62 million base pairs of DNA, making it similar in size to chromosome 19 and represents almost 2% of the total DNA in a male cell. [54] [55] The human Y chromosome carries 693 genes, 107 of which are protein-coding. [56]
In human genetics, a human Y-chromosome DNA haplogroup is a haplogroup defined by specific mutations in the non-recombining portions of DNA on the male-specific Y chromosome (Y-DNA). Individuals within a haplogroup share similar numbers of short tandem repeats (STRs) and single-nucleotide polymorphisms (SNPs). [ 2 ]
Haplogroup C is a major Y-chromosome haplogroup, defined by UEPs M130/RPS4Y711, P184, P255, and P260, which are all SNP mutations.It is one of two primary branches of Haplogroup CF alongside Haplogroup F.
Analysis of the Y chromosome is one of the methods used in tracing the history of early humans. Thirteen genetic markers on the Y-chromosome differentiate populations of human beings. It is believed, on the basis of genetic evidence, that all human beings in existence now descend from one single man who lived in Africa about 60,000 years ago. [2]
In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5]
Haplogroup A is a human Y-chromosome DNA haplogroup, which includes all living human Y chromosomes.Bearers of extant sub-clades of haplogroup A are almost exclusively found in Africa (or among the African diaspora), in contrast with haplogroup BT, bearers of which participated in the Out of Africa migration of early modern humans.
Among the six species, the Y chromosome exhibited much more variability than the X chromosome. For example, the X chromosomes of humans and chimpanzees are about 98 percent identical in makeup.
All these observations led to a consensus that a dominant gene that determines testis development must exist on the human Y chromosome. [38] The search for this testis-determining factor (TDF) led to Peter Goodfellow's team of scientists [ 39 ] in 1990 to discover a region of the Y chromosome that is necessary for the male sex determination ...