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Botulinum toxin is focal treatment, meaning that a limited number of muscles can be injected at the same time. The effect of the toxin is reversible and a reinjection may be needed every 4–6 months. [61] In children it decreases spasticity and improve range of motion and thus has become commonly used.
Treatment using botulinum toxin type B is comparable to type A, with an increased frequency of the side effect dry mouth. [ 10 ] [ 21 ] Common side effects include pain at the injection site (up to 28%), dysphagia due to the spread to adjacent muscles (11% to 40%), dry mouth (up to 33%), fatigue (up to 17%), and weakness of the injected or ...
Drugs such as baclofen, benzodiazepines (e.g., diazepam), tizanidine, and sometimes dantrolene have shown promise in the effort to diminish spasticity. [10] Botulinum toxin ("Botox") type A may reduce spasticity a few months at a time and has frequently been considered a beneficial treatment for children with SHCP and other forms of CP. [5]
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction , thus causing flaccid paralysis . [ 25 ]
Phenol injections can be used, or botulinum toxin [24] [18] [19] [25] injections into the muscle belly, to attempt to dampen the signals between nerve and muscle. The effectiveness of medications vary between individuals, and vary based on location of the upper motor neuron lesion (in the brain or the spinal cord).
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Botulinum toxin injections into affected muscles have proved quite successful in providing some relief for around 3–6 months, depending on the kind of dystonia. Botox or Dysport injections have the advantage of ready availability (the same form is used for cosmetic surgery) and the effects are not permanent.
List Labs was founded in 1978 [3] by Linda Shoer, and is headquartered in Campbell, California. [4] Starting with cholera, the firm developed bacterial proteins for research. When the firm was founded, and for many years after, it was the only manufacturer and supplier for several bacterial exotoxins and lipopolysaccharides (LPS). [5]
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