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It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations.
The prognosis of LATE varies significantly depending on several factors including the age at onset, stage of the disease at diagnosis, the presence and degree of cerebrovascular disease and of other comorbidities (particularly whether Alzheimer's disease pathology is also present), and individual patient factors. [71]
Compared to late onset dementia, patients with early onset dementia are more likely to have dementias other than Alzheimer's disease, although Alzheimer's is the most common etiology in either case. [13] In general, early onset dementia has a faster progression and features more extensive neurological damage when compared to late onset dementia.
When the disease is caused by autosomal dominant variants, it is known as early onset familial Alzheimer's disease, which is rarer and has a faster rate of progression. [17] Less than 5% of sporadic Alzheimer's disease have an earlier onset, [17] and early-onset Alzheimer's is about 90% heritable.
“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
Frontotemporal dementia (FTD) is an early onset disorder that mostly occurs between the ages of 45 and 65, [13] but can begin earlier, and in 20–25% of cases onset is later. [11] [14] Men and women appear to be equally affected. [15] It is the most common early presenting dementia. [16]
[279] [280] Less than 1% of those with Alzheimer's have gene mutations that cause a much earlier development of the disease, around the age of 45, known as early-onset Alzheimer's disease. [281] More than 95% of people with Alzheimer's disease have the sporadic form (late onset, 80–90 years of age). [281]
Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...