Search results
Results from the WOW.Com Content Network
The effect of these structural changes on behavior is uncertain and studies have produced conflicting results. Two studies [ 18 ] [ 19 ] have shown that an increase in dendritic spine density due to cocaine exposure facilitates behavioral sensitization , while two other studies [ 20 ] [ 21 ] produce contradicting evidence.
In 2005, scientists found surprisingly large quantities of benzoylecgonine in Italy's Po River and used its concentration to estimate the number of cocaine users in the region. [4] In 2006, a similar study was performed in the Swiss ski town of Saint-Moritz using wastewater to estimate the daily cocaine consumption of the population. [ 5 ]
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
UN World Drug Report 2016. In Peru, coca-bush cultivation jumped 44% between 2000 and 2011. While cultivation fell 31% between 2011 and 2014 (back to 2000 levels), it still accounts for 32% of ...
A key member of the Wnt signaling pathway, β-catenin, was thought to be induced by chronic cocaine administration (which had been true in the nucleus accumbens) but acute cocaine reduced expression in the caudate putamen whereas chronic cocaine injections decreased expression even in the NAc in D1 receptor mutants. This pathway influences ...
The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.
Most cocaine is grown and processed in South America, particularly in Colombia, Bolivia, Peru, and smuggled into the United States and Europe, the United States being the world's largest consumer of cocaine, [164] where it is sold at huge markups; usually in the US at $80–120 for 1 gram, and $250–300 for 3.5 grams ( 1 / 8 of an ounce ...
For premium support please call: 800-290-4726 more ways to reach us