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As haloperidol is a high-potency typical antipsychotic, it tends to produce significant extrapyramidal side effects. According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects. [29]
Neurology. Extrapyramidal symptoms (EPS) are symptoms that are archetypically associated with the extrapyramidal system of the brain's cerebral cortex. When such symptoms are caused by medications or other drugs, they are also known as extrapyramidal side effects (EPSE). The symptoms can be acute (short-term) or chronic (long-term).
fluphenazine and haloperidol: more extrapyramidal side effects (EPS) and less antihistaminic effects (e.g. sedation), alpha adrenergic antagonism (e.g. orthostatic hypotension), and anticholinergic effects (e.g. dry mouth) middle: perphenazine and loxapine: intermediate D2 affinity, with more off-target effects than high-potency agents low ...
Unwanted side effects cause people to stop treatment, resulting in relapses. [109] Risperidone (atypical) has a similar rate of extrapyramidal symptoms to haloperidol (typical). [108] A rare but potentially lethal condition of neuroleptic malignant syndrome (NMS) has been associated with the use of antipsychotics. Through its early recognition ...
Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia. [2] [3] [4
The first symptoms of neuroleptic malignant syndrome are usually muscle cramps and tremors, fever, symptoms of autonomic nervous system instability such as unstable blood pressure, and sudden changes in mental status (agitation, delirium, or coma). Other possible symptoms include sweating, trouble swallowing, tremors, incontinence, and mutism.
Akathisia (IPA: /æ.kə.ˈθɪ.si.ə/) is a movement disorder [5] characterized by a subjective feeling of inner restlessness accompanied by mental distress and/or an inability to sit still. [6][4] Usually, the legs are most prominently affected. [2] Those affected may fidget, rock back and forth, or pace, [7] while some may just have an uneasy ...
The terminology can still be imprecise. The definition of "atypicality" was based upon the absence of extrapyramidal side effects, but there is now a clear understanding that atypical antipsychotics can still induce these effects (though to a lesser degree than typical antipsychotics). [133]
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