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A standard cup of coffee can contain anywhere from 95 to 200 mg of caffeine. The FDA cites 400 mg of caffeine per day "as an amount not generally associated with dangerous, negative effects."
2. Coffee could help reduce your risk of Alzheimer’s ... “The caffeine in coffee can lead to increased heart rate ... which found that drinking 1.5 to 3.5 cups of coffee a day was associated ...
The risk was reduced by 48.1% if they had three cups a day, or 40.7% if they had 200 to 300 milligrams of caffeine daily, compared with people who didn’t drink or drank less than one cup, Ke said.
The study found any caffeine intake in general reduced risks of CM, although did not find strong evidence that tea reduced the risk of stroke and Type 2 Diabetes. By contrast, a 2011 review had found that drinking one to three cups of coffee per day may pose a slightly increased risk of developing hypertension. [22]
One study comparing various home-prepared samples came to the result that regular instant coffee (not decaffeinated) has a median caffeine content of 66 mg per cup (range 29–117 mg per cup), with a median cup size of 225 ml (range 170–285 ml) and a caffeine concentration of 328 μg/mL (range 102–559 μg/mL). [24]
Caffeine (1,3,7-trimethylxanthine) is the alkaloid most present in green and roasted coffee beans. The content of caffeine is between 1.0% and 2.5% by weight of dry green coffee beans. The content of caffeine does not change during maturation of green coffee beans, but higher caffeine content is found in plants grown at higher altitudes.
Specifically, consuming three 8-ounce cups of coffee or 200–300 mg of caffeine daily was associated with a 48.1% or 40.7% lower risk of cardiometabolic multimorbidity, respectively, compared to ...
Acute ingestion of caffeine in large doses (at least 250–300 mg, equivalent to the amount found in 2–3 cups of coffee or 5–8 cups of tea) results in a short-term stimulation of urine output in individuals who have been deprived of caffeine for a period of days or weeks. [92]