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TCF4 activates transcription by binding to the E-box (5’-CANNTG-3’) found usually on SSTR2 -INR, or somatostatin receptor 2 initiator element. TCF4 is primarily involved in neurological development of the fetus during pregnancy by initiating neural differentiation by binding to DNA. It is found in the central nervous system, somites, and ...
Specialty. Psychiatry, Medical genetics. Pitt–Hopkins syndrome ( PTHS) is a rare genetic disorder characterized by developmental delay, moderate to severe intellectual disability, [1] distinctive facial features, and possible intermittent hyperventilation followed by apnea. [2] Epilepsy (recurrent seizures)often occurs in Pitt-Hopkins. [1]
This is especially true for Healthy life expectancy, the definition of which criteria may change over time, even within a country. For example, Canada is a country with a fairly high overall life expectancy at 81.63 years; however, this number decreases to 75.5 years for Indigenous people in the country. [4]
TCF7L2. Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. [5] [6] The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. [7] [8] As a member of the TCF family, TCF7L2 can form a bipartite ...
The life expectancy in some states has fallen in recent years; for example, Maine's life expectancy in 2010 was 79.1 years, and in 2018 it was 78.7 years. The Washington Post noted in November 2018 that overall life expectancy in the United States was declining although in 2018 life expectancy had a slight increase of 0.1 and bringing it to ...
Life expectancy in the largest post-USSR countries located at the territory of Europe [ 2] Development of life expectancy in the countries of the South Caucasus. Map of the European countries by life expectancy in 2020 according to the World Bank. More than 82 years. Between 80 and 82 years. Between 78 and 80 years.
Life expectancy [161] increases with age already achieved. The table above gives the life expectancy at birth among 13th-century English nobles as 30–33, but having surviving to the age of 21, a male member of the English aristocracy could expect to live: 1200–1300: to age 64; 1300–1400: to age 45 (because of the bubonic plague)
Life expectancy in Canada in 2015-2017, 3-year average, by health regions. [4] [a] Data source: Statistics Canada. [1] [3] There are no data for Yukon for given periods. In 2014-2016 overall life expectancy in this territory was 78.68 years (75.92 for male and 81.47 for female).