Search results
Results from the WOW.Com Content Network
The atypical antipsychotics ( AAP ), also known as second generation antipsychotics ( SGAs) and serotonin –dopamine antagonists ( SDAs ), [ 1][ 2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely ...
Typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia ). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 5HT2A receptor antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics. [15]
There are two main categories of antipsychotics: typical and atypical. Typical antipsychotics have been around longer and are known as first-generation antipsychotics. Atypical antipsychotics are ...
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Cariprazine, sold under the brand name Vraylar among others, is an atypical antipsychotic developed by Gedeon Richter, [ 8 ] which is used in the treatment of schizophrenia, bipolar mania, [ 9 ] bipolar depression, [ 10 ] and major depressive disorder. [ 6 ]
The mechanism of actions of most antipsychotics is post-synaptic blockage of brain dopamine D2 receptors. Second generation antipsychotics also bind with serotonin 5HT2 receptors at a high affinity, which is suggested to be the cause for the lowered risk of extrapyramidal side effects compared with first generation antipsychotics. [14]
Psychopharmacology (from Greek ψῡχή, psȳkhē, 'breath, life, soul'; φάρμακον, pharmakon, 'drug'; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, behavior, judgment and evaluation, and memory. It is distinguished from neuropsychopharmacology, which emphasizes the correlation ...