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Bioinformatics tools aid in comparing, analyzing and interpreting genetic and genomic data and more generally in the understanding of evolutionary aspects of molecular biology. At a more integrative level, it helps analyze and catalogue the biological pathways and networks that are an important part of systems biology.
Biological data has also been difficult to define, as bioinformatics is a wide-encompassing field. Further, the question of what constitutes as being a living organism has been contentious, as "alive" represents a nebulous term that encompasses molecular evolution, biological modeling, biophysics, and systems biology.
Biological database design, development, and long-term management is a core area of the discipline of bioinformatics. [3] Data contents include gene sequences, textual descriptions, attributes and ontology classifications, citations, and tabular data. These are often described as semi- structured data, and can be represented as tables, key ...
Biological computation. The concept of biological computation proposes that living organisms perform computations, and that as such, abstract ideas of information and computation may be key to understanding biology. [1][2] As a field, biological computation can include the study of the systems biology computations performed by biota [3][4][5][6 ...
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. [1] An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. [2]
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. [1] More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access ...
The term structural has the same meaning as in structural biology, and structural bioinformatics can be seen as a part of computational structural biology. The main objective of structural bioinformatics is the creation of new methods of analysing and manipulating biological macromolecular data in order to solve problems in biology and generate ...
Usually, the term k -mer refers to all of a sequence's subsequences of length , such that the sequence AGAT would have four monomers (A, G, A, and T), three 2-mers (AG, GA, AT), two 3-mers (AGA and GAT) and one 4-mer (AGAT). More generally, a sequence of length will have − + k -mers and total possible k -mers, where is number of possible ...