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The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
While the systemic effects of testosterone are both expected and desired in both trans men and non-binary people using it, cisgender women generally do not want the other masculinizing effects of systemic testosterone. Applying cream or gel containing testosterone directly to the clitoris, rather than injecting it (the usual route of ...
[100] [101] [102] It is widely used in the treatment of acne, excessive hair growth, and hyperandrogenism in women, who have much lower testosterone levels than men. [98] [99] Because of its antimineralocorticoid activity, spironolactone has antimineralocorticoid side effects [103] and can cause high potassium levels.
[4] [1] [5] It has also been used to treat breast cancer in women. [6] It is given by injection into muscle usually once every two to three days. [5] [7] [8] Side effects of testosterone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. [5]
[49] [28] High dosages of testosterone (with levels of > 50 ng/dL) have a risk of masculinization (e.g., acne, hair growth, voice changes) with long-term therapy in women. [ 49 ] [ 28 ] High dosages of testosterone but not low dosages of testosterone enhance the effects of low dosages of estrogens on sexual desire.
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