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It is advised that women with a normal weight before pregnancy should gain a total of 11.5 kilograms to 16.0 kilograms throughout gestation, which is approximately 0.4 kilogram per week in the second and third trimesters. [3] In order to maintain a steady weight gain, the mother should engage in mild physical activities.
DES gained notoriety when it was shown to cause a rare vaginal tumor in girls and young women who had been exposed to this drug in utero.In 1971, the New England Journal of Medicine published a report showing that seven of eight girls and young women (ages 14 to 22) who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. [5]
Whether use during pregnancy is safe is unclear, but use while breastfeeding is probably safe, since the dose the infant receives is 1–2% that of the maternal dose, on a weight basis. [23] [18] Buprenorphine was patented in 1965, and approved for medical use in the United States in 1981.
During pregnancy, a woman's mass increases by about 12 kg (26 lb). [39] The European Food Safety Authority recommends an increase of 300 mL per day compared to the normal intake for non-pregnant women, taking the total adequate water intake (from food and fluids) to 2,300 mL, or approximately 1,850 mL/ day from fluids alone. [40]
The IOM has recommended the ranges of weight gain to be 12.5–18 kg, 11.5–16 kg, 7-11.5 kg, and 5–9 kg respectively. That is, the smaller the BMI pre pregnancy, the more weight a woman is expected to gain during her pregnancy. [3]
Fetal macrosomia, maternal obesity and excessive weight gain during pregnancy are associated with later obesity in childhood and adolescence. [7] As early as at age 6 years, children of women who were obese before they became pregnant had more often a cardiometabolic risk profile compared to children of normal-weight mothers.
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. (Reminder that there are many of these meds now.
Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone. [3] It is used to treat opioid use disorder, and reduces the mortality of opioid use disorder by 50% (by reducing the risk of overdose on full-agonist opioids such as heroin or fentanyl).