Search results
Results from the WOW.Com Content Network
An abrupt and major increase in the rate of hospitalization due to hyperkalemia from 0.2% to 11% and in the rate of death due to hyperkalemia from 0.3 per 1,000 to 2.0 per 1,000 between early 1994 and late 2001 has been attributed to a parallel rise in the number of prescriptions written for spironolactone upon the publication of the Randomized ...
Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism.
[2] [3] [1] [4] Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of ...
The trial was stopped early because the beneficial effect of spironolactone on all-cause death exceeded the prespecified discontinuation requirements. Spironolactone reduced the risk of death by 30% compared to placebo. Additionally, there was a 35% reduction in the risk of hospitalization for worsening heart failure in the spironolactone group.
A Detroit mom has been charged with murder after "smothering" and choking her 9-year-old son to death, burying him in a backyard grave and then skipping town, according to prosecutors.
Nearly 1,000 arrests were made by ICE in the days after Trump, 78, was sworn into office on Jan. 20, the BBC reported Jan. 26.. The 956 reported arrests included 286 arrests on Saturday, Jan. 25 ...
Canrenone is an antagonist of the MR as is spironolactone, [25] but it is slightly more potent in comparison. [24] [26] It has been determined that 7α-TMS accounts for around 80% of the potassium-sparing effect of spironolactone [1] [2] [3] while canrenone accounts for the remaining approximately 10 to 25%. [4]
For the first time in two decades, the Food and Drug Administration (FDA) has approved a new class of medication that provides an alternative to addictive opioids for patients looking to manage ...