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The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [4] The 5-HT 2A receptor is a cell surface receptor, [5] but has several intracellular locations. [6] Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11-protein coupled.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
The 5-HT 2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1] The 5-HT 2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to G q /G 11 and mediate excitatory neurotransmission , [ 2 ] including 5-HT 2A , 5-HT 2B , and 5-HT 2C .
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G q /G 11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, [4] [5] that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed ...
Based upon its structure and connectivity, its function is suggested to be related to coordination of different brain functions; i.e. the conductor analogy. Consciousness functionally can be divided into two components: (i) wakefulness, which is arousal and alertness; (ii) content of consciousness, which is the processing of content.
In order to function properly the serotonin transporter requires the membrane potential created by the sodium-potassium adenosine triphosphatase. The serotonin transporter first binds a sodium ion, followed by the serotonin , and then a chloride ion; it is then allowed, thanks to the membrane potential, to flip inside the cell freeing all the ...